CIC Press Release
A new APIOS press release!
Read full article about Read more about CIC Press Release3D Bioactive Implant for Bone Self-Repair
Transforming the future of bone healing with innovative solutions.
The Challenge in Bone Repair
Understanding the critical issues in current bone repair methods
Bone fractures are very common traumas. Today, 10% of bone defects don't repair, and it can reach 45% for risk patients (diabetes, elderly, osteoporosis, smokers).
In the case of severe trauma, the standard solution is autograft but the amount of available bone is limited, and the surgical procedure is painful for the patient.
10%
Defects don't repair
45%
Risk patients
Our Innovative Solution
Advanced 3D bioactive implants that revolutionize bone self-repair
APIOS develops 3D bioactive implants to stimulate bone self-repair. The implant is a scaffold made by 3D printing, which allows control size, shape, and porosity. It can be custom-made for the patient.
Internal and external surfaces are coated with a biomimetic film containing an osteo-inductive protein (BMP-2), which activates bone repair. The 3D bioactive implant is ready-to-use for the surgeon, which simplify the surgical procedure.
Osteo conductive
Scaffold structure promotes bone growth
Osteo inductive
BMP-2 protein coating activates bone repair
Custom made
3D printed to match patient needs
Ready to use
Simplified surgical procedure
Apios Applications
Discover how our technology is transforming various medical procedures
Dental / Maxillo-facial
Orthopedics
Spinal Fusion
News
Latest news
Biolabs Investor Day 2025
We are very happy to have been selected by CNRS Innovation to PITCH our APIOS project at Biolabs Investor Day, the 11st of March 2025 in Paris. See you there!
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Tech and Fest 2025
We were proud to participate to Tech & Fest 2025 on CNRS space. Thank you for the discussions.
Read full article about Read more about Tech and Fest 2025Latest Updates & Research
Explore our scientific publications, patents, and media coverage
Publications
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3D-Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical-Size Bone Defect.
DOI: 10.1002/adhm.202301692 -
Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics.
DOI: 10.1002/adfm.202006967 -
3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect.
DOI: 10.1016/j.mtbio.2021.100113 -
Surface delivery of tunable doses of BMP-2 from an adaptable polymeric scaffold induces volumetric bone regeneration.
DOI: 10.1016/j.biomaterials.2016.06.001
Patents
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Implantable medical device for bone repair.
WO2022063771A1 -
Process for preparing a surface coated by crosslinked polyelectrolyte multilayer films as a biomimetic reservoir for proteins.
WO2010081884A2
Media Coverage
- Press release CIC magazine Presence
- Press release Grenoble INP
- Press release Blog CNRS
- Podcast La chronique Santé de Thierry Lhermitte
- Press release Le Dauphiné Libéré
Our Team
Meet our dedicated team of experts working to revolutionize bone repair technology
Prof. Abhay PANDIT
Founding Director of a Research Ireland Centre for Research in Medical Devices (CÚRAM)
Prof. Youssef HAIKEL
Honorary Dean at Faculty of Dental Surgery of Strasbourg
Dr. Jean-Pierre BRUN
Dental surgeon
Expert in Dental Implantology
Contact Us
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